Author Archives: lrnlab

Nigrostriatal changes with MAO-B Inhibitor in Parkinson’s Disease

Abstract Rasagiline is a monoamine oxidase type B inhibitor that possesses no amphetamine-like properties, and provides symptomatic relief in early and late stages of Parkinson’s disease (PD). Data in animal models of PD suggest that chronic administration of rasagiline is … Continue reading

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Free-water diffusion imaging in Parkinson’s disease and Parkinsonism

Link to paper Abstract Conventional single tensor diffusion analysis models have provided mixed findings in the substantia nigra of Parkinson’s disease, but recent work using a bi-tensor analysis model has shown more promising results. Using a bi-tensor model, free-water values … Continue reading

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Pain and motor processing in the human cerebellum

Abstract Pain-related adaptions in movement require a network architecture that allows for integration across pain and motor circuits. Previous studies addressing this issue have focused on cortical areas such as the midcingulate cortex. Here we focus on pain and motor … Continue reading

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Progression of Parkinson’s Disease and Substantia Nigra

Abstract There is a clear need to develop non-invasive markers of substantia nigra progression in Parkinson’s disease. We previously found elevated free-water levels in the substantia nigra for patients with Parkinson’s disease compared with controls in single-site and multi-site cohorts. … Continue reading

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Novel technique to estimate cortical rhythms in the cortex during upper limb movement

Abstract Precise motor control requires the ability to scale the parameters of movement. Theta oscillations across the cortex have been associated with changes in memory, attention, and sensorimotor processing. What has proven more elusive is pinpointing the region-specific frequency band … Continue reading

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Multiple system atrophy and Parkinson’s disease show different brain patterns

Abstract Parkinson’s disease (PD) and the parkinsonian variant of multiple system atrophy (MSAp) are neurodegenerative disorders that can be difficult to differentiate clinically. This study provides the first characterization of the patterns of task-related functional magnetic resonance imaging (fMRI) changes … Continue reading

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Bi-tensor model detects increased free-water in the substantia nigra of Parkinson’s disease across MRI sites

Abstract Measures from diffusion magnetic resonance imaging reflect changes in the substantia nigra of Parkinson’s disease. It is the case, however, that partial volume effects from free-water can bias diffusion measurements. The bi-tensor diffusion model was introduced to quantify the … Continue reading

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Subthalamic nucleus and motor cortex connectivity impaired in Parkinson’s disease

Kurani et al. 2014 Neurobiology of Aging PDF Link Here Abstract: Previous research has indicated increased functional connectivity between subthalamic nucleus (STN) and sensorimotor cortex in off-medication Parkinson’s disease (PD) compared with control subjects. It is not clear if the … Continue reading

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Essential tremor pathophysiology linked to cortex and cerebellum

Neely et al. (2014) Cerebral Cortex PDF Link Here Abstract It is well-established that during goal-directed motor tasks, patients with essential tremor have increased oscillations in the 0–3 and 3–8 Hz bands. It remains unclear if these increased oscillations relate … Continue reading

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New article published in PLoS ONE: Dose-response effect of isometric force production on the perception of pain

PLoS One. 2014 Feb 4;9(2):e88105. doi: 10.1371/journal.pone.0088105. eCollection 2014. Dose-response effect of isometric force production on the perception of pain. Misra G, Paris TA, Archer DB, Coombes SA. http://www.ncbi.nlm.nih.gov/pubmed/24505397 Isometric contractions can influence the way that we perceive pain, but … Continue reading

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