{"id":1659,"date":"2015-05-20T17:36:29","date_gmt":"2015-05-20T21:36:29","guid":{"rendered":"https:\/\/lrnlab.org\/?p=1659"},"modified":"2015-05-20T17:36:29","modified_gmt":"2015-05-20T21:36:29","slug":"progression-of-parkinsons-disease-and-substantia-nigra","status":"publish","type":"post","link":"https:\/\/lrnlab.org\/?p=1659","title":{"rendered":"Progression of Parkinson&#8217;s Disease and Substantia Nigra"},"content":{"rendered":"<p>Abstract<br \/>\nThere is a clear need to develop non-invasive markers of substantia nigra progression in Parkinson&#8217;s disease. We previously found elevated free-water levels in the substantia nigra for patients with Parkinson&#8217;s disease compared with controls in single-site and multi-site cohorts. Here, we test the hypotheses that free-water levels in the substantia nigra of Parkinson&#8217;s disease increase following 1 year of progression, and that baseline free-water levels in the substantia nigra predict the change in bradykinesia following 1 year. We conducted a longitudinal study in controls (n = 19) and patients with Parkinson&#8217;s disease (n = 25). Diffusion imaging and clinical data were collected at baseline and after 1 year. Free-water analyses were performed on diffusion imaging data using blinded, hand-drawn regions of interest in the posterior substantia nigra. A group effect indicated free-water values were increased in the posterior substantia nigra of patients with Parkinson&#8217;s disease compared with controls (P = 0.003) and we observed a significant group \u00d7 time interaction (P < 0.05). Free-water values increased for the Parkinson's disease group after 1 year (P = 0.006), whereas control free-water values did not change. Baseline free-water values predicted the 1 year change in bradykinesia scores (r = 0.74, P < 0.001) and 1 year change in Montreal Cognitive Assessment scores (r = -0.44, P = 0.03). Free-water in the posterior substantia nigra is elevated in Parkinson's disease, increases with progression of Parkinson's disease, and predicts subsequent changes in bradykinesia and cognitive status over 1 year. These findings demonstrate that free-water provides a potential non-invasive progression marker of the substantia nigra.\n\n<a href=\"https:\/\/lrnlab.org\/wp-content\/uploads\/2015\/05\/Longitudinal-Changes-in-SN-2015.pdf\">Longitudinal Changes in SN 2015<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract There is a clear need to develop non-invasive markers of substantia nigra progression in Parkinson&#8217;s disease. We previously found elevated free-water levels in the substantia nigra for patients with Parkinson&#8217;s disease compared with controls in single-site and multi-site cohorts. Here, we test the hypotheses that free-water levels in the substantia nigra of Parkinson&#8217;s disease [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[1],"tags":[],"class_list":["post-1659","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/lrnlab.org\/index.php?rest_route=\/wp\/v2\/posts\/1659","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lrnlab.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lrnlab.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lrnlab.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lrnlab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1659"}],"version-history":[{"count":1,"href":"https:\/\/lrnlab.org\/index.php?rest_route=\/wp\/v2\/posts\/1659\/revisions"}],"predecessor-version":[{"id":1661,"href":"https:\/\/lrnlab.org\/index.php?rest_route=\/wp\/v2\/posts\/1659\/revisions\/1661"}],"wp:attachment":[{"href":"https:\/\/lrnlab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1659"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lrnlab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1659"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lrnlab.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1659"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}