{"id":2169,"date":"2019-12-19T08:15:10","date_gmt":"2019-12-19T13:15:10","guid":{"rendered":"https:\/\/lrnlab.org\/?p=2169"},"modified":"2019-12-19T08:15:12","modified_gmt":"2019-12-19T13:15:12","slug":"free-water-in-hippocampus-is-more-sensitive-than-volume","status":"publish","type":"post","link":"https:\/\/lrnlab.org\/?p=2169","title":{"rendered":"Free-water in hippocampus is more sensitive than volume"},"content":{"rendered":"\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Ofori%20E%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=31470214\">Ofori E<\/a><sup>1<\/sup>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=DeKosky%20ST%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=31470214\">DeKosky ST<\/a><sup>2<\/sup>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Febo%20M%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=31470214\">Febo M<\/a><sup>3<\/sup>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Colon-Perez%20L%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=31470214\">Colon-Perez L<\/a><sup>4<\/sup>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Chakrabarty%20P%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=31470214\">Chakrabarty P<\/a><sup>5<\/sup>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Duara%20R%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=31470214\">Duara R<\/a><sup>6<\/sup>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Adjouadi%20M%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=31470214\">Adjouadi M<\/a><sup>7<\/sup>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Golde%20TE%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=31470214\">Golde TE<\/a><sup>5<\/sup>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Vaillancourt%20DE%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=31470214\">Vaillancourt DE<\/a><sup>8<\/sup>;\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Alzheimer%27s%20Disease%20Neuroimaging%20Initiative%5BCorporate%20Author%5D\">Alzheimer&#8217;s Disease Neuroimaging Initiative<\/a>.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31470214\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31470214<\/a><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>Validating sensitive markers of hippocampal degeneration is fundamental for understanding neurodegenerative conditions such as Alzheimer&#8217;s disease. In this paper, we test the hypothesis that free-water in the hippocampus will be more sensitive to early stages of cognitive decline than hippocampal volume, and that free-water in hippocampus will increase across distinct clinical stages of Alzheimer&#8217;s disease. We examined two separate cohorts (N\u202f=\u202f126; N\u202f=\u202f112) of cognitively normal controls, early and late mild cognitive impairment (MCI), and Alzheimer&#8217;s disease. Demographic, clinical, diffusion-weighted and T1-weighted imaging, and positron emission tomography (PET) imaging were assessed. Results indicated elevated hippocampal free-water in early MCI individuals compared to controls across both cohorts. In contrast, there was no difference in volume of these regions between controls and early MCI. ADNI free-water values in the hippocampus was associated with low CSF AB<sub>1-42<\/sub>\u00a0levels and high global amyloid PET values. Free-water imaging of the hippocampus can serve as an early stage marker for AD and provides a complementary measure of AD neurodegeneration using non-invasive imaging.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ofori E1,\u00a0DeKosky ST2,\u00a0Febo M3,\u00a0Colon-Perez L4,\u00a0Chakrabarty P5,\u00a0Duara R6,\u00a0Adjouadi M7,\u00a0Golde TE5,\u00a0Vaillancourt DE8;\u00a0Alzheimer&#8217;s Disease Neuroimaging Initiative. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31470214 Validating sensitive markers of hippocampal degeneration is fundamental for understanding neurodegenerative conditions such as Alzheimer&#8217;s disease. In this paper, we test the hypothesis that free-water in the hippocampus will be more sensitive to early stages of cognitive decline than hippocampal volume, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2169","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/lrnlab.org\/index.php?rest_route=\/wp\/v2\/posts\/2169","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lrnlab.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lrnlab.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lrnlab.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lrnlab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2169"}],"version-history":[{"count":1,"href":"https:\/\/lrnlab.org\/index.php?rest_route=\/wp\/v2\/posts\/2169\/revisions"}],"predecessor-version":[{"id":2170,"href":"https:\/\/lrnlab.org\/index.php?rest_route=\/wp\/v2\/posts\/2169\/revisions\/2170"}],"wp:attachment":[{"href":"https:\/\/lrnlab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2169"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lrnlab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2169"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lrnlab.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2169"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}