Dr. Jesse DeSimone is a neuroscientist and Postdoctoral Researcher in the Laboratory for Rehabilitation Neuroscience. He completed his PhD in Applied Physiology and Kinesiology at the University of Florida in 2019. Dr. DeSimone’s research focuses on understanding disease-related adaptations to structural and functional brain systems using a combination of big-data, biomedical image analysis, and informatics. The overarching goal is to develop reliable tools and technologies that will enable early and accurate diagnosis of neurological disease and provide readout measures for evaluating disease-modifying therapeutics. His current work is focused on using diffusion imaging and machine learning to understand brain microstructure changes during the earliest biological stages of Alzheimer’s disease and related dementias.