Stephen Coombes

Professor

I co-founded the Laboratory for Rehabilitation Neuroscience at the University of Florida in 2011. My research focusses on brain structure and brain function in human models of neurodegeneration and other disorders that affect the sensorimotor system. My group has been at the cutting-edge of developing novel neuroimaging paradigms to study pain physiology, motor systems physiology, and diffusion MRI analysis approaches for understanding brain microstructure in disease. My body of work is documented in over 80 peer-reviewed publications in journals that include PAIN, Cerebral Cortex, Neurology, Lancet, Human Brain Mapping, Journal of Pain, Journal of Physiology, and Neuroimage. As PI, my laboratory has active NIH funded projects in the areas of chronic pain and Alzheimer’s Disease. I am also co-I on several NIH funded projects that use my motor and pain paradigms to understand brain function in shoulder pain, stroke, and autism. I am a Co-I and member of the 1FLORIDA Alzheimer’s Disease Research Center Biomarker Core, co-mentor on a K23, and mentor on NIH-T32 and NIH-T90/R90 training awards in pain and aging.

Research Interests
Dr. Stephen Coombes’ research focuses on brain structure and brain function in human models of neurodegeneration and other disorders that affect the sensorimotor system..
 

Selected Publications

  • Ho, R. L. M., Park, J., Wang, W. E., Thomas, J. S., Cruz-Almeida, Y., & Coombes, S. A. (2024). Lower individual alpha frequency in individuals with chronic low back pain and fear of movement. Pain, 165(5), 1033–1043. https://doi.org/10.1097/j.pain.0000000000003098
  • DeSimone, J. C., Wang, W. en, Loewenstein, D. A., Duara, R., Smith, G. E., McFarland, K. N., Armstrong, M. J., Weber, D. M., Barker, W., Coombes, S. A., & Vaillancourt, D. E. (2024). Diffusion MRI relates to plasma Aβ42/40 in PET negative participants without dementia. Alzheimer’s and Dementia, 20(4), 2830–2842. https://doi.org/10.1002/alz.13693
  • Park, J., Ho, R. L. M., Wang, W. en, Nguyen, V. Q., & Coombes, S. A. (2024). The effect of age on alpha rhythms in the human brain derived from source localized resting-state electroencephalography. NeuroImage, 292. https://doi.org/10.1016/j.neuroimage.2024.120614
  • Park, J., Nguyen, V. Q., Ho, R. L. M., & Coombes, S. A. (2023). The effect of chronic low back pain on postural control during quiet standing: A meta-analysis. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-34692-w
  • Wang, W. en, Asken, B. M., DeSimone, J. C., Levy, S. A., Barker, W., Fiala, J. A., Velez-Uribe, I., Curiel Cid, R. E., Rósselli, M., Marsiske, M., Adjouadi, M., Loewenstein, D. A., Duara, R., Smith, G. E., Armstrong, M. J., Barnes, L. L., Vaillancourt, D. E., & Coombes, S. A. (2024). Neuroimaging and biofluid biomarkers across race and ethnicity in older adults across the spectrum of cognition. Ageing Research Reviews, 101. https://doi.org/10.1016/j.arr.2024.102507
 

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