Author Archives: lrnlab

Free-water in hippocampus is more sensitive than volume

Ofori E1, DeKosky ST2, Febo M3, Colon-Perez L4, Chakrabarty P5, Duara R6, Adjouadi M7, Golde TE5, Vaillancourt DE8; Alzheimer’s Disease Neuroimaging Initiative. https://www.ncbi.nlm.nih.gov/pubmed/31470214 Validating sensitive markers of hippocampal degeneration is fundamental for understanding neurodegenerative conditions such as Alzheimer’s disease. In this paper, we test the hypothesis that free-water in … Continue reading

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New study on DBS in Essential Tremor

https://www.ncbi.nlm.nih.gov/pubmed/31794958 OBJECTIVE:  Essential tremor (ET) prominently affects the upper-limbs during voluntary movements, but can also affect the lower-limbs, head, and chin. Although deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) of thalamus improves both clinical ratings and quantitative … Continue reading

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NEW Transcallosal Tract Template (TCATT)

Development of a transcallosal tractography template and its application to dementia. Archer DB, Coombes SA, McFarland NR, DeKosky ST, Vaillancourt DE https://www.ncbi.nlm.nih.gov/pubmed/31260838 Abstract Understanding the architecture of transcallosal connections would allow for more specific assessments of neurodegeneration across many fields of neuroscience, neurology, and … Continue reading

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New article in PAIN – Functional Imaging in Chronic Pain

Link to site Functional brain activity during motor control and pain processing in chronic jaw pain Roy, Arnaba; Wang, Wei-en; Ho, Rachel L.M.; Ribeiro-Dasilva, Margarete C.; Fillingim, Roger B; Coombes, Stephen A. Changes in brain function in chronic pain have … Continue reading

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Biomarkers in Parkinson’s – Science Trans Med

Biomarkers Perspective Published in Science Translational Medicine http://stm.sciencemag.org/content/10/454/eaam6003    

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Beta Band EEG Relates to Putamen fMRI in Parkinson

Download Paper Abstract We investigated the effect of acute levodopa administration on movement-related cortical oscillations and movement velocity in Parkinson’s disease (PD). Patients with PD on and off medication and age- and sex-matched healthy controls performed a ballistic upper limb … Continue reading

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Recruiting PhD Students 2018

We are actively recruiting PhD students for the Fall 2018 semester. We use a range of systems neuroscience techniques that include functional magnetic resonance imaging (fMRI), structural MRI, diffusion imaging (DTI), electromyography (EMG), high-density electroencephalography (EEG), and pain stimulation procedures. … Continue reading

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NIH Press Release

Press Release Here

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Validated Progression Marker of Parkinson’s Disease

Article here Abstract Progression markers of Parkinson’s disease are crucial for successful therapeutic development. Recently, a diffusion magnetic resonance imaging analysis technique using a bitensor model was introduced allowing the estimation of the fractional volume of free water within a … Continue reading

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Functional Imaging Predicts Dystonia Symptoms

Abstract Burciu et al. (2017) https://www.ncbi.nlm.nih.gov/pubmed/28594097 Cervical dystonia (CD) is the most common type of focal dystonia, causing abnormal movements of the neck and head. In this study, we used noninvasive imaging to investigate the motor system of patients with … Continue reading

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