Author Archives: lrnlab

New paper in Neuroimage – Somatotopic organization in the human brain

Unraveling somatotopic organization in the human brain using machine learning and adaptive supervoxel-based parcellations Link to abstract 2021 Dec 15;245:118710. doi: 10.1016/j.neuroimage.2021.118710. Epub 2021 Nov 12.   Kyle B See, David J Arpin, David E Vaillancourt, Ruogu Fang, Stephen A Coombes   In addition … Continue reading

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New Dystonia Paper in Science Translational Medicine

Link to paper Abstract: Dystonias are a group of chronic movement–disabling disorders for which highly effective oral medications or disease-modifying therapies are lacking. The most effective treatments require invasive procedures such as deep brain stimulation. In this study, we used … Continue reading

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Cell-specific effects of a Dyt1 knock-out model

Abstract Pubmed Link DYT1 dystonia is a debilitating movement disorder characterized by repetitive, unintentional movements and postures. The disorder has been linked to mutation of the TOR1A/DYT1 gene encoding torsinA. Convergent evidence from studies in humans and animal models suggest … Continue reading

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Cortical dynamics of movement-evoked pain in chronic low back pain

Wei-En Wang  1 , Rachel L M Ho  1 , Bryan Gatto  2 , Susanne M van der Veen  3 , Matthew K Underation  3 , James S Thomas  3 , Ajay B Antony  4 , Stephen A Coombes  1 https://pubmed.ncbi.nlm.nih.gov/33067807/ Abstract: Although experimental pain alters neural … Continue reading

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Free-water in hippocampus is more sensitive than volume

Ofori E1, DeKosky ST2, Febo M3, Colon-Perez L4, Chakrabarty P5, Duara R6, Adjouadi M7, Golde TE5, Vaillancourt DE8; Alzheimer’s Disease Neuroimaging Initiative. https://www.ncbi.nlm.nih.gov/pubmed/31470214 Validating sensitive markers of hippocampal degeneration is fundamental for understanding neurodegenerative conditions such as Alzheimer’s disease. In this paper, we test the hypothesis that free-water in … Continue reading

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New study on DBS in Essential Tremor

https://www.ncbi.nlm.nih.gov/pubmed/31794958 OBJECTIVE:  Essential tremor (ET) prominently affects the upper-limbs during voluntary movements, but can also affect the lower-limbs, head, and chin. Although deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) of thalamus improves both clinical ratings and quantitative … Continue reading

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NEW Transcallosal Tract Template (TCATT)

Development of a transcallosal tractography template and its application to dementia. Archer DB, Coombes SA, McFarland NR, DeKosky ST, Vaillancourt DE https://www.ncbi.nlm.nih.gov/pubmed/31260838 Abstract Understanding the architecture of transcallosal connections would allow for more specific assessments of neurodegeneration across many fields of neuroscience, neurology, and … Continue reading

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New article in PAIN – Functional Imaging in Chronic Pain

Link to site Functional brain activity during motor control and pain processing in chronic jaw pain Roy, Arnaba; Wang, Wei-en; Ho, Rachel L.M.; Ribeiro-Dasilva, Margarete C.; Fillingim, Roger B; Coombes, Stephen A. Changes in brain function in chronic pain have … Continue reading

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Biomarkers in Parkinson’s – Science Trans Med

Biomarkers Perspective Published in Science Translational Medicine http://stm.sciencemag.org/content/10/454/eaam6003    

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Beta Band EEG Relates to Putamen fMRI in Parkinson

Download Paper Abstract We investigated the effect of acute levodopa administration on movement-related cortical oscillations and movement velocity in Parkinson’s disease (PD). Patients with PD on and off medication and age- and sex-matched healthy controls performed a ballistic upper limb … Continue reading

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