Author Archives: lrnlab

Functional Imaging Predicts Dystonia Symptoms

Abstract Burciu et al. (2017) https://www.ncbi.nlm.nih.gov/pubmed/28594097 Cervical dystonia (CD) is the most common type of focal dystonia, causing abnormal movements of the neck and head. In this study, we used noninvasive imaging to investigate the motor system of patients with … Continue reading

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A Template and Probabilistic Atlas of the Human Sensorimotor Tracts using Diffusion MRI.

Cereb Cortex. 2017 Mar 14:1-15. doi: 10.1093/cercor/bhx066. [Epub ahead of print] A Template and Probabilistic Atlas of the Human Sensorimotor Tracts using Diffusion MRI. Archer DB, Vaillancourt DE, Coombes SA. Abstract The purpose of this study was to develop a … Continue reading

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Automated classification of pain perception using HD-EEG

J Neurophysiol. 2016 Nov 30:jn.00650.2016. doi: 10.1152/jn.00650.2016. [Epub ahead of print] Automated Classification of Pain Perception using High Density Electroencephalography Data. Misra G, Wang WE, Archer DB, Roy A, Coombes SA1. Translating brief millisecond-long pain-eliciting stimuli to the subjective perception … Continue reading

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Beta Oscillations Linked to Accuracy of Movement

Abstract Accurate motor performance may depend on the scaling of distinct oscillatory activity within the motor cortex and effective neural communication between the motor cortex and other brain areas. Oscillatory activity within the beta-band (13-30Hz) has been suggested to provide … Continue reading

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Imaging neural circuits in DYT1 Dystonia reveals new insight

Abstract Developing in vivo functional and structural neuroimaging assays in Dyt1 ΔGAG heterozygous knock-in (Dyt1 KI) mice provide insight into the pathophysiology underlying DYT1 dystonia. In the current study, we examined in vivo functional connectivity of large-scale cortical and subcortical … Continue reading

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Microstructural properties of premotor pathways predict visuomotor performance in chronic stroke

Hum Brain Mapp. 2016 Feb 27. doi: 10.1002/hbm.23155. Microstructural properties of premotor pathways predict visuomotor performance in chronic stroke. Archer DB, Misra G, Patten C, Coombes SA. http://www.ncbi.nlm.nih.gov/pubmed/26920656 Microstructural properties of the corticospinal tract (CST) descending from the motor cortex … Continue reading

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Pain-Related Suppression of Beta Oscillations Facilitates Voluntary Movement

Cereb Cortex. 2016 Mar 10. pii: bhw061. Pain-Related Suppression of Beta Oscillations Facilitates Voluntary Movement. Misra G, Ofori E, Chung JW, Coombes SA. http://www.ncbi.nlm.nih.gov/pubmed/26965905 Increased beta oscillations over sensorimotor cortex are antikinetic. Motor- and pain-related processes separately suppress beta oscillations … Continue reading

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Nigrostriatal changes with MAO-B Inhibitor in Parkinson’s Disease

Abstract Rasagiline is a monoamine oxidase type B inhibitor that possesses no amphetamine-like properties, and provides symptomatic relief in early and late stages of Parkinson’s disease (PD). Data in animal models of PD suggest that chronic administration of rasagiline is … Continue reading

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Free-water diffusion imaging in Parkinson’s disease and Parkinsonism

Link to paper Abstract Conventional single tensor diffusion analysis models have provided mixed findings in the substantia nigra of Parkinson’s disease, but recent work using a bi-tensor analysis model has shown more promising results. Using a bi-tensor model, free-water values … Continue reading

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Pain and motor processing in the human cerebellum

Abstract Pain-related adaptions in movement require a network architecture that allows for integration across pain and motor circuits. Previous studies addressing this issue have focused on cortical areas such as the midcingulate cortex. Here we focus on pain and motor … Continue reading

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