Laboratory for Rehabilitation Neuroscience
Unraveling somatotopic organization in the human brain using machine learning and adaptive supervoxel-based parcellations Link to abstract 2021 Dec 15;245:118710. doi: 10.1016/j.neuroimage.2021.118710. Epub 2021 Nov 12. Kyle B See, David J Arpin, David E Vaillancourt, Ruogu Fang, Stephen A Coombes In addition to the well-established somatotopy in the pre- and post-central gyrus, there is now strong evidence […]
Wei-En Wang 1 , Rachel L M Ho 1 , Bryan Gatto 2 , Susanne M van der Veen 3 , Matthew K Underation 3 , James S Thomas 3 , Ajay B Antony 4 , Stephen A Coombes 1 https://pubmed.ncbi.nlm.nih.gov/33067807/ Abstract: Although experimental pain alters neural activity in the cortex, evidence of changes in neural activity in individuals with chronic low […]
Cereb Cortex. 2016 Mar 10. pii: bhw061. Pain-Related Suppression of Beta Oscillations Facilitates Voluntary Movement. Misra G, Ofori E, Chung JW, Coombes SA. http://www.ncbi.nlm.nih.gov/pubmed/26965905 Increased beta oscillations over sensorimotor cortex are antikinetic. Motor- and pain-related processes separately suppress beta oscillations over sensorimotor cortex leading to the prediction that ongoing pain should facilitate movement. In the […]
Abstract Pain-related adaptions in movement require a network architecture that allows for integration across pain and motor circuits. Previous studies addressing this issue have focused on cortical areas such as the midcingulate cortex. Here we focus on pain and motor processing in the human cerebellum. The goal in the current study was to identify areas […]
http://www.asbweb.org/conferences/2012/posters/clinical.html 142 – Distinct Features of Grip Force Characterize Parkinson’s Disease and Atypical Parkisonian Disorders Neely K, Planetta P, Prodoehl J, Corcos D, Comella C, Goetz C, Shannon K, Vaillancourt D University of Florida http://www.asbweb.org/conferences/2012/posters/imaging.html 20 – Thalamic Projection Fiber Integrity in De Novo Parkinson’s Disease Planetta P, Schulze E, Geary E, Goldman J, Corcos […]
This research examines the neural mechanisms underlying action inhibition, which is the cancellation of an initiated motor response. Healthy adults exhibit flexible motor behavior whereas adults with Parkinson’s disease (PD) experience difficulty inhibiting action. In particular, PD patients demonstrate a specific deficit turning off muscle activity. The goal of this grant is to develop a […]
Thalamic projection fiber integrity in de novo Parkinson’s disease Background and Purpose: Post-mortem studies of advanced Parkinson’s disease (PD) have revealed disease-related pathology in the thalamus with an apparent predilection for specific thalamic nuclei. In the present study, we used diffusion tensor imaging (DTI) to investigate in vivo the microstructural integrity of six thalamic regions […]
Parkinson’s disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and essential tremor (ET) affect over 10 million people in the United States. These debilitating movement disorders can be very difficult to distinguish from each other, have different prognoses, and can respond very differently (if at all) to available therapies. The purpose of this […]
Understanding brain function during visually guided movements after stoke is important because assessment and rehabilitation approaches involve visually guided movements. The current proposal will first characterize how stroke influences brain activity during a visually guided grip task, and second, will manipulate visual feedback during the task to increase activity in specific regions of the affected […]
Spatiotemporal dynamics of brain activity during the transition from visually guided to memory guided force control. It is well established that the prefrontal cortex is involved during memory guided tasks whereas visually guided tasks are controlled in part by a frontal-parietal network. However, the nature of the transition from visually guided to memory guided force […]