Laboratory for Rehabilitation Neuroscience
Thalamic projection fiber integrity in de novo Parkinson’s disease Background and Purpose: Post-mortem studies of advanced Parkinson’s disease (PD) have revealed disease-related pathology in the thalamus with an apparent predilection for specific thalamic nuclei. In the present study, we used diffusion tensor imaging (DTI) to investigate in vivo the microstructural integrity of six thalamic regions […]
Parkinson’s disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and essential tremor (ET) affect over 10 million people in the United States. These debilitating movement disorders can be very difficult to distinguish from each other, have different prognoses, and can respond very differently (if at all) to available therapies. The purpose of this […]
Understanding brain function during visually guided movements after stoke is important because assessment and rehabilitation approaches involve visually guided movements. The current proposal will first characterize how stroke influences brain activity during a visually guided grip task, and second, will manipulate visual feedback during the task to increase activity in specific regions of the affected […]
Spatiotemporal dynamics of brain activity during the transition from visually guided to memory guided force control. It is well established that the prefrontal cortex is involved during memory guided tasks whereas visually guided tasks are controlled in part by a frontal-parietal network. However, the nature of the transition from visually guided to memory guided force […]